Finally, β-secretase activity is insensitive to pepstatin, an inhibitor of many (but not all) aspartic proteases. During 1999–2000, five teams concluded that ...
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beta-Secretase as a therapeutic target for Alzheimer's disease - PubMed
pubmed.ncbi.nlm.nih.gov › ...
beta-Secretase (memapsin 2, BACE1) is an attractive target for the development of inhibitor drugs to treat Alzheimer's disease (AD).
Missing: Hydrolase Complex
Nov 15, 2007 · Finally, β-secretase activity is insensitive to pepstatin, an inhibitor of many (but not all) aspartic proteases. During 1999–2000, five teams ...
Jul 3, 2013 · β-Secretase initiates the cleavage of APP and has been identified as the transmembrane aspartic protease beta-site APP cleaving enzyme 1 (BACE1) ...
Another piece of evidence that PSs provide the catalytic core for the aspartyl protease activity of the γ‐secretase complex is that γ‐secretase inhibitors can ...
-. Basic information · PROTEASE · ALZHEIMER'S DISEASE · ASPARTIC PROTEASE · ASPARTYL PROTEASE · BETA-SECRETASE · GLYCOPROTEIN · HYDROLASE · MEMAPSIN 2 ...
Jun 30, 2014 · The amyloid cascade hypothesis, adapted from Citron (2004). The pathogenic events shown can eventually lead to Alzheimer's disease (AD). The ...
Memapsin 2 is a membrane-associated aspartic protease involved in the production of β-amyloid peptide in Alzheimer's disease and is a major target for drug ...
Feb 4, 2015 · ... complex with 2 ... Classification: Hydrolase/hydrolase inhibitor ... beta-secretase inhibitors for the potential treatment of Alzheimer's disease.
Mar 10, 2022 · Here, we disclose a class of 6-chlorotacrine (huprine)–TPPU hybrids as dual inhibitors of the enzymes soluble epoxide hydrolase (sEH) and ...